How to describe, analyze and interrogate dynamics of gene regulatory networks
Talk by Dr. Tomas Gedeon (Mathematical Sciences, MSU)
10/22/2020 3:10 pm WebEx Meeting
We first describe mathematical foundation of DSGRN (Dynamic Signatures Generated by Regulatory Networks), an approach that provides a queryable description of global dynamics of a network over its entire parameter space. We describe a connection to Boolean network models that allows us to view DSGRN as a platform for bifurcation theory of Boolean maps.
We describe several applications. We show how to use DSGRN to
(1) Design a network that performs a biological function;
(2) Diagnose why a synthetic network failed, and
(3) Delineate dynamics of network that governs epithelial-mesenchymal transition, which allows cells to escape confinement of a tissue and migrate.